입수한 문건의 말을 빌리면, 우울감 부작용 보고는 적은 숫자가 아니었다. 2006년부터 MSD는 프로페시아를 복용하는 여성들에게서 자살 충동을 배합한 500개 이상의 우울감 보고를 받았다. 다만 MSD는 심각한 우울감과 자살 행동에 대한 보고가 너무 적으며, 안전성에 대한 모니터링 이상을 요구할만큼 구체적인 사례가 없다는 이유로 후속조치를 하지 않았다.
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